Catlytic type: Cysteine; activates itself by cleaving the Lys62|+|Gly bond, and the newly exposed N-terminal Gly is then lipid-modified.  Amongst other proteins, only those with a prenylated cysteine are substrates. Substrates include RhoA, the Rac and Cdc42 GTPases and host serine/threonine kinase PBS1 (which is cleaved at a single bond: <%Zhu, M. %etal, 2004[20040510A717]%>).; act as transamidases by attaching a lipid moiety to the newly exposed N-terminus of the substrate; RhoA, the Rac and Cdc42 GTPases and host serine/threonine kinase PBS1
Endopeptidases that also act as transamidases, attaching a lipid moiety to the newly exposed N-terminus of the substrate