Catlytic type: Metallo; DPPIII releases N-terminal dipeptides sequentially from a peptide.  Angiotensins II and III, Leu-enkephalin, prolactin and alpha-melanocyte-stimulating hormone are readily cleaved, whereas tripeptides are poor substrates and angiotensin I and polypeptides of more than ten residues are not cleaved.  In addition, proline is not accepted in P1 or P1&rsquo; .  The recommended synthetic substrate is Arg-Arg|+|NHMec (<%Chen & Barrett, 2004[20040525A373]%>).; polypeptides of more than ten residues are not cleaved and proline in the P1 or P1 position will not cleave
Dipeptidylpeptidase